With more and more airlines announcing flights from Australia to San Francisco (Qantas just announced flights from Brisbane and Sydney) you may find your self passing through San Francisco Airport (SFO) at the beginning or end of your journey. We recently flew from Sydney to San Francisco at the start of our around the world trip and found the airport to be very easy to navigate, with plenty of spots to sit and relax before your next flight.
We had an early morning flight so luckily the airport was not very busy when we arrived, and check-in and bag drop were even easier with clearly marked signs for the cabin classes and airlines (this may differ depending on your airline).